Tuesday, February 12, 2013

Designers take some risks in menswear at New York Fashion Week

NEW YORK (Reuters) - Designers livened up fall and winter 2013 menswear at New York Fashion Week with a few experimental touches in the otherwise staid world of men's clothing.

A bold show came from Duckie Brown, one of the hundreds of designers showing at the official Mercedes Benz Fashion Week at Manhattan's Lincoln Center and venues elsewhere in the city.

Fashion Week in New York, which ends on Thursday, is followed by similar events in London, Paris and Milan.

Reversing the conventions of men's' layering, the Duckie Brown line by New York-based designers Steven Cox and Daniel Silver showed short jackets worn over longer coats or over-sized knee-length sweatshirts, giving the illusion the models were wearing skirts.

Coupled with dark wool trousers with deep inverted ankle cuffs in burgundy or turquoise, the effect evoked the traditional robe-like costume of a Himalayan kingdom.

In another challenge to convention, Duckie Brown showed backward coats -- at the front, a blank facade of wool and at the back, a fastening down to the ankles.

The designers also showed a bright indigo suit cut from thick wool, so bulky and seemingly inflexible it brought to mind a figure made of plastic Lego toy bricks.

Wool in its stoutest forms made its mark at the menswear show by Joseph Abboud, whose creative director Bernada Rojo said he was inspired by "the energy of the determined daredevils and enterprising leaders who put a man on the moon."

Abboud offered a metallic, chainmail-like sweater and bulky wool trousers in rich green, with ribbed patches at the knees, utility pockets and thick elastic ankle cuffs looking like refined versions of what an astronaut might wear as an insulating layer underneath a spacesuit.

At DKNY's menswear, there were slim-fitting, single-breasted two-button suits in gray, black and navy that might make a decent impression on Wall Street.

"The palette is all New York," said notes accompanying the show.

DKNY's casual wear items were safe variations on a familiar slouchy, urban theme -- sweaters, anoraks and bomber jackets in muted greens, blues and grays, accessorized with black beanie caps and no-nonsense black shoes.

Timo Weiland, a label by New York-based designers Weiland and Alan Eckstein, took a similar mood and color scheme in a cuter, more idiosyncratic direction.

Blazers were tweedy, in speckled wool. One outfit, surprisingly successful, resembled a jacket thrown over a pair of pajamas in a natty brown circle-patterned print. A blue sweater bore a folksy image of a dachshund -- Eckstein owns one -- across the chest.

Things were a little more rugged in the Nautica men's collection, where accompanying notes for the show said the season's clothes were inspired by the nautical expeditions of Antarctic explorer Sir Ernest Shackleton.

The collection added flourishes to Nautica's trademark naval jackets and fisherman cable-knit sweaters. One parka featured glowing colored lights woven into the edge of the hood.

Puffer jackets were cut in unusually exaggerated silhouettes, bulky at the shoulders, tightly scooped in at the waist and flaring back out at the thigh.

Nylon and wool utility-style pants fiercely hugged the models' thighs and calves. Turtlenecks, as at Joseph Abboud, were about as high as was practicable.

(Editing by Ellen Wulfhorst and David Gregorio)

Source: http://news.yahoo.com/designers-risks-menswear-york-fashion-week-232332888.html

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New strategy for interfering with potent cancer-causing gene

Feb. 11, 2013 ? Acute myeloid leukemia (AML) is an aggressive blood cancer that is currently incurable in 70% of patients. In a bold effort, CSHL scientists are among those identifying and characterizing the molecular mechanisms responsible for this cancer in order to generate potential new therapeutics.

CSHL Assistant Professor Christopher Vakoc, M.D., Ph.D., and colleagues, including the group of Professor Robert Roeder Ph.D. at The Rockefeller University, report the characterization of a protein required for AML in a paper published February 11 in the Proceedings of the National Academy of Sciences.

Screening of DNA packaging proteins calls attention to RNF20

About 5%-10% of AML is characterized by the rearrangement of a gene called MLL (Mixed-Lineage Leukemia). The MLL fusion proteins that result from this rearrangement are potent oncogenes -- cancer-causing genes. They are particularly common in infant acute leukemia, which is usually resistant to standard chemotherapy.

An emerging body of evidence implicates problems with chromatin, the packaging material for DNA within the cell nucleus, as a major cause of acute leukemia. Based on this, Vakoc's laboratory is searching for novel drug targets among chromatin proteins, with the hope of identifying new ways to fight this disease.

"We sifted through a class of proteins that add 'protein tags' to chromatin in a search for new therapeutic targets," says Eric Wang, a former technician in the Vakoc lab who led this study. Wang is currently a doctoral student at Johns Hopkins University. These 'protein tags' are called ubiquitin and constitute one of many ways to control which genes are switched 'ON' or 'OFF' in our cells.

The team identified a protein called RNF20 that attaches ubiquitin tags to chromatin as being essential for the formation of leukemias caused by MLL-rearrangements. When they suppressed the expression of RNF20, the researchers were able to decrease leukemia cell proliferation in living mice, extending their lifespan.

Upon closer examination, the team realized that by targeting RNF20 they prevent MLL-fusion proteins from being able to work. "When we reduce the levels of RNF20 in leukemia cells, they revert back to being more like normal blood cells," says Shinpei Kawaoka, a postdoc in the Vakoc lab who also was involved in the study.

Vakoc's team proposes a model in which leukemia cells of the MLL-rearranged subtype come to rely on RNF20 to maintain their gene expression program, implicating it as a potential therapeutic target. Small-molecule drugs that target other proteins involved in regulating ubiquitin tags already exist so it is possible that drugs targeting RNF20 could be developed in the future for the treatment of MLL-rearranged leukemia.

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The above story is reprinted from materials provided by Cold Spring Harbor Laboratory, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Eric Wang, Shinpei Kawaoka, Ming Yu, Junwei Shi, Ting Ni, Wenjing Yang, Jun Zhu, Robert G. Roeder and Christopher R. Vakoc. Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia. Proceedings of the National Academy, 2013 DOI: 10.1073/pnas.201301045

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/yv9pnabEOGc/130211162329.htm

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Visualizing biological networks in 4-D

Feb. 11, 2013 ? Every great structure, from the Empire State Building to the Golden Gate Bridge, depends on specific mechanical properties to remain strong and reliable. Rigidity?a material's stiffness?is of particular importance for maintaining the robust functionality of everything from colossal edifices to the tiniest of nanoscale structures. In biological nanostructures, like DNA networks, it has been difficult to measure this stiffness, which is essential to their properties and functions. But scientists at the California Institute of Technology (Caltech) have recently developed techniques for visualizing the behavior of biological nanostructures in both space and time, allowing them to directly measure stiffness and map its variation throughout the network.

The new method is outlined in the February 4 early edition of the Proceedings of the National Academy of Sciences (PNAS).

"This type of visualization is taking us into domains of the biological sciences that we did not explore before," says Nobel Laureate Ahmed Zewail, the Linus Pauling Professor of Chemistry and professor of physics at Caltech, who coauthored the paper with Ulrich Lorenz, a postdoctoral scholar in Zewail's lab. "We are providing the methodology to find out?directly?the stiffness of a biological network that has nanoscale properties."

Knowing the mechanical properties of DNA structures is crucial to building sturdy biological networks, among other applications. According to Zewail, this type of visualization of biomechanics in space and time should be applicable to the study of other biological nanomaterials, including the abnormal protein assemblies that underlie diseases like Alzheimer's and Parkinson's.

Zewail and Lorenz were able to see, for the first time, the motion of DNA nanostructures in both space and time using the four-dimensional (4D) electron microscope?developed at Caltech's Physical Biology Center for Ultrafast Science and Technology. The center is directed by Zewail, who created it in 2005 to advance understanding of the fundamental physics of chemical and biological behavior.

"In nature, the behavior of matter is determined by its structure?the arrangements of its atoms in the three dimensions of space?and by how the structure changes with time, the fourth dimension," explains Zewail. "If you watch a horse gallop in slow motion, you can follow the time of the gallops, and you can see in detail what, for example, each leg is doing over time. When we get to the nanometer scale, that is a different story?we need to improve the spatial resolution to a billion times that of the horse in order to visualize what is happening."

Zewail was awarded the 1999 Nobel Prize in Chemistry for his development of femtochemistry, which uses ultrashort laser flashes to observe fundamental chemical reactions occurring at the timescale of the femtosecond (one millionth of a billionth of a second). Although femtochemistry can capture atoms and molecules in motion, giving the time dimension, it cannot concurrently show the dimensions of space, and thus the structure of the material. This is because it utilizes laser light with wavelengths that far exceed the dimension of a nanostructure, making it impossible to resolve and image nanoscale details in tiny physical structures such as DNA .

To overcome this major hurdle, the 4D electron microscope employs a stream of individual electrons that scatter off objects to produce an image. The electrons are accelerated to wavelengths of picometers, or trillionths of a meter, providing the capability for visualizing the structure in space with a resolution a thousand times higher than that of a nanostructure, and with a time resolution of femtoseconds or longer.

The experiments reported in PNAS began with a structure created by stretching DNA over a hole embedded in a thin carbon film. Using the electrons in the microscope, several DNA filaments were cut away from the carbon film so that a three-dimensional, free-standing structure was achieved under the 4D microscope.

Next, the scientists employed laser heat to excite oscillations in the DNA structure, which were imaged using the electron pulses as a function of time?the fourth dimension. By observing the frequency and amplitude of these oscillations, a direct measure of stiffness was made.

"It was surprising that we could do this with a complex network," says Zewail. "And yet by cutting and probing, we could go into a selective area of the network and find out about its behavior and properties."

Using 4D electron microscopy, Zewail's group has begun to visualize protein assemblies called amyloids, which are believed to play a role in many neurodegenerative diseases, and they are continuing their investigation of the biomechanical properties of these networks. He says that this technique has the potential for broad applications not only to biological assemblies, but also in the materials science of nanostructures.

Funding for the research outlined in the PNAS paper, "Biomechanics of DNA structures visualized by 4D electron microscopy," was provided by the National Science Foundation and the Air Force Office of Scientific Research. The Physical Biology Center for Ultrafast Science and Technology at Caltech is supported by the Gordon and Betty Moore Foundation.

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Story Source:

The above story is reprinted from materials provided by California Institute of Technology. The original article was written by Katie Neith.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. U. J. Lorenz, A. H. Zewail. Biomechanics of DNA structures visualized by 4D electron microscopy. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1300630110

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/jmTEFjyS0NU/130211135013.htm

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Gun violence victims will attend Obama's speech to Congress (reuters)

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Monday, February 11, 2013

Black Keys Guitarist Dan Auerbach & Wife Divorcing

Black Keys Guitarist Dan Auerbach & Wife Divorcing

Dan Auerbach of The Black Keys picsBlack Keys guitarist Dan Auerbach may have had a big night last night at the Grammys, landing the Producer of the Year award and three awards for his band. But Auerbach’s personal life isn’t going quite so well. The rocker and his wife Stephanie Gonis have reportedly split. Dan’s wife Stephanie was noticeably absent from ...

Black Keys Guitarist Dan Auerbach & Wife Divorcing Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2013/02/black-keys-guitarist-dan-auerbach-wife-divorcing/

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Fantasy Baseball 2013: Ranking Top Players Eligible for Multiple Positions

Having a player who is eligible for multiple positions can only help you in fantasy baseball.

It allows you to have flexibility with your lineup and gives you space to add pieces here and there while still maintaining a high level of production at each position.

Here are five players eligible for multiple positions who are worth nabbing in your fantasy drafts.

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5. Joe Mauer, C/1B, Minnesota Twins

When Joe Mauer stays on the field, he's one of the best hitters in the game.?Of course, he has to stay on the field.

Mauer surprisingly played in 147 games for the Twins last season, batting .319 with 85 RBI and 81 runs.?On the other hand, he's a 29-year-old catcher with a history of injuries.

It's not realistic to expect Mauer to play a full season, but his ADP (average draft position) is relatively low compared to what he can do when he's on the field. He's worth a gamble at the catcher position considering only three catchers (Mauer, Buster Posey and Yadier Molina) hit over .300 last season.

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4. Ben Zobrist, OF/2B/SS, Tampa Bay Rays

Ben Zobrist had a career year in 2012, hitting .270 with 20 home runs, 74 RBI, 88 runs and 14 stolen bases.?

The 31-year-old hit .292 after the All-Star break in 2012 and he's eligible at second base, shortstop and outfield.

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3. Allen Craig, 1B/OF, St. Louis Cardinals

Allen Craig has been turning heads ever since 2011, when he hit .315 with 11 home runs, 40 RBI and 33 runs in 200 at-bats for the Cardinals.

Last season, Craig had a career year, batting .307 with 22 home runs, 92 RBI and 76 runs. On top of that, he was consistent, batting over .300 before and after the All-Star break.

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2. Hanley Ramirez, 3B/SS, Los Angeles Dodgers

After a rough 2011 campaign, Hanley Ramirez didn't play much better for the Marlins in 2012.

But after being dealt to the Los Angeles Dodgers before the trade deadline, the three-time All-Star got in a groove, hitting .282 with seven home runs, 26 RBI and 15 runs in August.

Ramirez's eligibility as a shortstop makes him valuable in 2013 if he can get back on track.

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1. Buster Posey, C/1B, San Francisco Giants

In Buster Posey's rookie season, he won the National League Rookie of the Year. After a freak collision derailed his sophomore campaign in 2011, he bounced back in tremendous fashion, earning the NL Comeback Player of the Year award, as well as being named the 2012 NL MVP.

As the MLB batting champion last season, Posey hit .336 with 24 home runs, 103 RBI and 78 runs.

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Source: http://bleacherreport.com/articles/1524361-fantasy-baseball-2013-ranking-top-players-eligible-for-multiple-positions

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Tornado causes significant damage in Mississippi town of Hattiesburg

HATTIESBURG, Miss. (AP) ? A tornado tore through Hattiesburg on Sunday as part of a wave of severe storms that downed trees, damaged buildings and injured at least three people.

The twister traveled down one of Hattiesburg's main streets and mangled homes, commercial buildings and several structures on the campus of the University of Southern Mississippi. The state emergency management agency said it was only aware of three injuries in the state, all in a county to the west of Hattiesburg.

Mississippi Emergency Management Agency spokesman Greg Flynn said it appears that a single tornado caused the damage in three counties.

On the campus of the university, trees were snapped in half around the heavily damaged Alumni House where part of the roof was ripped away. Windows in a nearby building were blown out, and heavy equipment worked to clear streets nearby in a heavy rain after the worst of the weather had passed.

The university released a statement saying no one was hurt but that it was under a state of emergency, anyone away from campus should stay away until further notice.

East of campus, 47-year-old Cindy Bullock was at home with her husband and dog, a terrier mix named Vinnie, when she heard the tornado coming. They ran to a hallway and covered their heads. It wasn't long before the windows in the kitchen and bedroom exploded. The storm stripped all the shingles off the roof and left holes in it, while knocking over a large pine tree in the yard.

After dark, the Bullocks were trying to arrange their stuff inside so it wouldn't get wet from the dripping water.

"I just looked out the window and I heard the rumbling. It sounded like a train. We ran to the hall, and the kitchen windows and the windows in the bedroom exploded. It happened pretty fast," she said.

There were large trees blocking the road all through her neighborhood, and several of the houses were hit by falling trees. Her friend was staying with them after the friend's apartment took a direct hit from a falling tree.

To the west, Marion County emergency director Aaron Greer says three injuries have been reported in the community of Pickwick, about seven miles south of Columbia. He says two people were taken to hospitals, but the third didn't have the injury examined.

Greer says one mobile home was destroyed, three other structures have major damage and several have minor damage.

Gov. Phil Bryant plans to go to Hattiesburg on Monday to check out damage in the city and at USM, his alma mater, spokesman Mick Bullock said.

___

Associated Press writer Janet McConnaughey in New Orleans contributed to this report.

Source: http://news.yahoo.com/significant-storm-damage-hattiesburg-miss-001411837.html

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